Fetal liver hematopoiesis: from development to delivery
نویسندگان
چکیده
منابع مشابه
Apoptosis and hematopoiesis in murine fetal liver.
The fetal mouse liver (FL) is an organ of intense, but transient, hematopoietic activity during mid-gestation, with erythropoiesis being predominant during days 11 through 16. It therefore seemed reasonable to expect that hematopoietic cytokines, such as erythropoietin (epo), interleukin-3 (IL-3), and stem cell factor (SCF), may play important roles in maintaining a homeostatic balance of eryth...
متن کاملApoptosis and Hematopoiesis in Murine Fetal Liver
The fetal mouse liver (FL) is an organ of intense, but transient, hematopoietic activity during mid-gestation, with erythropoiesis being predominant during days 1 1 through 16. It therefore seemed reasonable to expect that hematopoietic cytokines, such as erythropoietin (epo), interleukin-3 (IL-3). and stem cell factor (SCF), may play important roles in maintaining a homeostatic balance of eryt...
متن کاملEarly oleate deficiency leads to severe defects in fetal rat liver development
Objective(s): Oleate can be produced through de novo synthesis, which contributes to biological processes and signaling pathways. However, the role of this non-essential fatty acid in hepatic development remains unclear. The current study aimed to evaluate the influence of early oleate deficiency induced by the inhibitor of de novo oleate synthesis MF-438 on fetal rat ...
متن کاملHepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis.
Embryonic liver is a transient site for definitive hematopoiesis. Along with maturation of the bone marrow and spleen, hematopoietic cells relocate from the liver to their final destinations while the liver starts organizing its own structure and develops numerous metabolic functions toward adult. Recently, it was demonstrated that the signal exerted by oncostatin M (OSM) through gp130 plays a ...
متن کاملHEMATOPOIESIS Cited2 is required for normal hematopoiesis in the murine fetal liver
Cited2 (cAMP-responsive elementbinding protein [CBP]/p300-interacting transactivators with glutamic acid [E] and aspartic acid [D]–rich tail 2) is a newly identified transcriptional modulator. Knockout of the Cited2 gene results in embryonic lethality with embryos manifesting heart and neural tube defects. Cited2 / fetal liver displayed significant reduction in the numbers of Lin cKit Sca-1 cel...
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ژورنال
عنوان ژورنال: Stem Cell Research & Therapy
سال: 2021
ISSN: 1757-6512
DOI: 10.1186/s13287-021-02189-w